Tag Archives: infectious disease

Addressing the Global Challenge of Ebola and Infectious Disease Outbreaks

On Wednesday, July 17th, 2019, the World Health Organization (WHO) Emergency Committee released a statement declaring the Ebola outbreak in the Democratic Republic of the Congo (DRC) an international emergency. The statement announced that, on average, 80 new cases are reported each week along the northeastern border of the DRC. Because thousands cross this border to Rwanda daily, the national and regional risk is very high. Furthermore, the US Department of State now considers the North Kivu and Ituri Provinces in the DRC a “Level 4: Do Not Travel” zone due to the threats to safety caused by local conflicts and the Ebola outbreak. Preexisting unstable political conditions, poor security and limited infection control practices add to the complexity of the situation. Two community health workers were murdered last week, contributing to the unrest. Now the disease has reached Goma, a city with nearly two million people and an international airport, leading WHO to take action.

According to WHO, the virus continues to spread geographically, despite improvements in outbreak surveillance and decreases in virus transmissions. Additional resources, local community involvement, increased security measures, and efforts across multiple sectors are still necessary to control this outbreak. Our reports explore recent Ebola outbreaks, infectious disease control and prevention, and global health policy, and provide guidance for decision-making. All reports are free to read or download.

 

Integrating Clinical Research into Epidemic Response: The Ebola Experience

The 2014–2015 Ebola epidemic in western Africa was the longest and most deadly Ebola epidemic in history, resulting in 28,616 cases and 11,310 deaths in Guinea, Liberia, and Sierra Leone. The Ebola virus has been known since 1976, when two …

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Global Health and the Future Role of the United States

While much progress has been made on achieving the Millenium Development Goals over the last decade, the number and complexity of global health challenges has persisted. Growing forces for globalization have increased the interconnectedness of …

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The Neglected Dimension of Global Security: A Framework to Counter Infectious Disease Crises

Since the 2014 Ebola outbreak many public- and private-sector leaders have seen a need for improved management of global public health emergencies. The effects of the Ebola epidemic go well beyond the three hardest-hit countries and beyond the …

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The Animal-Human Link to Infectious Disease

Long-eared_BatBats are the most populous mammal—with more than 1,200 species representing around 25% of all mammal species—and are found in all parts of the world except for the North and South poles and some remote islands. Although they carry a number of viruses without symptoms (e.g., SARS, Hendra, Nipah, and Ebola), little is known about their response to disease. The Institute of Medicine’s new report Emerging Viral Diseases discusses the use of nontraditional animal models — like bats — to study the development of disease, host-virus relationships, and the nature of the immune responses to particular diseases.

As human and animal populations grow and encroach on each other’s habitats, the likelihood of zoonotic diseases increases. Changes in climate and rapid movement of increasingly more people and goods around the world make infectious disease more difficult to contain. Reports from the Institute of Medicine address the challenges of surveillance and response to these threats. All are free to download.

Emerging Viral Diseases: The One Health Connection: Workshop Summary

In the past half century, deadly disease outbreaks caused by novel viruses of animal origin – Nipah virus in Malaysia, Hendra virus in Australia, Hantavirus in the United States, Ebola virus in Africa, along with HIV (human immunodeficiency …

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Achieving Sustainable Global Capacity for Surveillance and Response to Emerging Diseases of Zoonotic Origin: Workshop Summary

One of the biggest threats today is the uncertainty surrounding the emergence of a novel pathogen or the re-emergence of a known infectious disease that might result in disease outbreaks with great losses of human life and immense global economic …

[more]

Sustaining Global Surveillance and Response to Emerging Zoonotic Diseases

H1N1 (“swine flu”), SARS, mad cow disease, and HIV/AIDS are a few examples of zoonotic diseases-diseases transmitted between humans and animals. Zoonotic diseases are a growing concern given multiple factors: their often novel and unpredictable …

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Infectious Disease Movement in a Borderless World: Workshop Summary

Modern transportation allows people, animals, and plants–and the pathogens they carry–to travel more easily than ever before. The ease and speed of travel, tourism, and international trade connect once-remote areas with one another, eliminating …

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The Institute of Medicine on the US Measles Outbreak

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Photo credit: KidRisk.org

MMR – measles, mumps, rubella – vaccination is again in the news as an outbreak of measles that began at Disneyland before Christmas has spread to six states. As of last Friday, 70 people have been diagnosed with measles, and hundreds more have been exposed at schools, doctor’s offices, hospitals, shopping malls and other places visited by infected patients. Arizona reported its first case of measles related to Disneyland when a woman in her 50s was diagnosed. The outbreak has spread to Utah, Washington, Colorado, Oregon and across the border to Mexico. The Institute of Medicine has produced a number of reports on the safety and importance of vaccination. We asked Kathleen Stratton, an Institute of Medicine Scholar and Study Director of several notable IOM reports on vaccines, for her thoughts on vaccination and public health.

“Vaccines save lives. That’s a fact. We need vaccines developed against some very serious infectious diseases, like respiratory syncytial virus, and we need everyone to heed advice regarding existing vaccines, like the measles vaccine.”

The reports below and others on the subject of vaccination are free to download from our website.

The Childhood Immunization Schedule and Safety: Stakeholder Concerns, Scientific Evidence, and Future Studies

Vaccines are among the most safe and effective public health interventions to prevent serious disease and death. Because of the success of vaccines, most Americans today have no firsthand experience with such devastating illnesses as polio or …

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Infectious Disease Movement in a Borderless World: Workshop Summary

Modern transportation allows people, animals, and plants–and the pathogens they carry–to travel more easily than ever before. The ease and speed of travel, tourism, and international trade connect once-remote areas with one another, eliminating …

[more]

What You Need to Know About Infectious Disease

About a quarter of deaths worldwide–many of them children–are caused by infectious organisms. The World Health Organization reports that new infectious diseases are continuing to emerge and familiar ones are appearing in new locations around …

[more]

Adverse Effects of Vaccines: Evidence and Causality

In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed …

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Immunization Safety Review: Vaccines and Autism

This eighth and final report of the Immunization Safety Review Committee examines the hypothesis that vaccines, specifically the measles-mumps-rubella (MMR) vaccine and thimerosal-containing vaccines, are causally associated with autism. The …

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Science and Infectious Disease: Resources to Understand the Ebola Outbreak

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This photo shows MSF (Médecins Sans Frontières) health staff in protective clothing constructing perimeter for an Ebola isolation ward.

The Ebola outbreak in West Africa has killed more than 670 people and spread to four countries. The disease has no vaccine and no specific treatment. It has a fatality rate of at least 60%. What do we know about infectious diseases, and what can we do to monitor and prevent their spread? Reports of the Institute of Medicine and the National Academies are a great resource to understand the science that will be critical to resolving this crisis. All are free to download.

Infectious Disease Movement in a Borderless World: Workshop Summary

Modern transportation allows people, animals, and plants–and the pathogens they carry–to travel more easily than ever before. The ease and speed of travel, tourism, and international trade connect once-remote areas with one another, eliminating …

[more]

Sustaining Global Surveillance and Response to Emerging Zoonotic Diseases

H1N1 (“swine flu”), SARS, mad cow disease, and HIV/AIDS are a few examples of zoonotic diseases-diseases transmitted between humans and animals. Zoonotic diseases are a growing concern given multiple factors: their often novel and unpredictable …

[more]

Vector-Borne Diseases: Understanding the Environmental, Human Health, and Ecological Connections, Workshop Summary (Forum on Microbial Threats)

Vector-borne infectious diseases, such as malaria, dengue fever, yellow fever, and plague, cause a significant fraction of the global infectious disease burden; indeed, nearly half of the world’s population is infected with at least one type of …

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What You Need to Know About Infectious Disease

About a quarter of deaths worldwide–many of them children–are caused by infectious organisms. The World Health Organization reports that new infectious diseases are continuing to emerge and familiar ones are appearing in new locations around …

[more]

Global Climate Change and Extreme Weather Events: Understanding the Contributions to Infectious Disease Emergence: Workshop Summary

Long before the “germ theory” of disease was described, late in the nineteenth century, humans knew that climatic conditions influence the appearance and spread of epidemic diseases. Ancient notions about the effects of weather and climate on …

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Achieving Sustainable Global Capacity for Surveillance and Response to Emerging Diseases of Zoonotic Origin: Workshop Summary

One of the biggest threats today is the uncertainty surrounding the emergence of a novel pathogen or the re-emergence of a known infectious disease that might result in disease outbreaks with great losses of human life and immense global economic …

[more]