Tag Archives: biomedical research

New Frontiers of Biomedical Science: Possibilities and Issues

Credit: American Cancer Institute

As scientific advances have made genome editing and other biomedical technologies more efficient, precise, and flexible than ever before, scientists, patients, and others have been exploring possible ways in which this cutting-edge science can improve human health. Our titles consider both the potential benefits and the scientific, ethical, legal, social, and governance issues associated with the use of gene-editing tools and other new technologies. As always, all are free to read online or download.

The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance

The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance

Each year, tens of millions of individuals in the U.S. suffer from neurological and psychiatric disorders including neurodegenerative diseases such as Alzheimer’s Disease and Parkinson’s Disease, and psychiatric disorders such as autism spectrum disorder, depression and schizophrenia. Treatments for these diseases are often completely …[more]

Next Steps for Functional Genomics: Proceedings of a Workshop

Next Steps for Functional Genomics: Proceedings of a Workshop

One of the holy grails in biology is the ability to predict functional characteristics from an organism’s genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism’s phenotype, its physical …[more]

Heritable Human Genome Editing

Heritable Human Genome Editing

Heritable human genome editing – making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy – raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have …[more]

Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting: Proceedings of a Workshop

Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting: Proceedings of a Workshop

Sharing knowledge is what drives scientific progress – each new advance or innovation in biomedical research builds on previous observations. However, for experimental findings to be broadly accepted as credible by the scientific community, they must be verified by other researchers. An essential step is for researchers to report their findings …[more]

Safeguarding the Bioeconomy

Safeguarding the Bioeconomy

Research and innovation in the life sciences is driving rapid growth in agriculture, biomedical science, information science and computing, energy, and other sectors of the U.S. economy. This economic activity, conceptually referred to as the bioeconomy, presents many opportunities to create jobs, improve the quality of life, and continue to …[more]

Framework for Addressing Ethical Dimensions of Emerging and Innovative Biomedical Technologies: A Synthesis of Relevant National Academies Reports

Framework for Addressing Ethical Dimensions of Emerging and Innovative Biomedical Technologies: A Synthesis of Relevant National Academies Reports

Over the past 15 years, the National Academies of Sciences, Engineering, and Medicine (the National Academies) have convened multiple committees of leading experts to address ethical challenges related to innovative and emerging biomedical technologies. After reviewing prior National Academies’ reports, individual ethics principles and …[more]

Second International Summit on Human Genome Editing: Continuing the Global Discussion: Proceedings of a Workshop–in Brief

Second International Summit on Human Genome Editing: Continuing the Global Discussion: Proceedings of a Workshop–in Brief

On November 27-29, 2018, the U.S. National Academy of Sciences and U.S. National Academy of Medicine, the Royal Society of the United Kingdom, and the Academy of Sciences of Hong Kong convened the Second International Summit on Human Genome Editing at the University of Hong Kong. The summit brought together more than 500 researchers, ethicists, …[more]

Understanding Disparities in Access to Genomic Medicine: Proceedings of a Workshop

Understanding Disparities in Access to Genomic Medicine: Proceedings of a Workshop

Genomic medicine is defined as the routine use of genomic information about an individual as part of his or her clinical care as well as the health outcomes and policy implications of that clinical use. It is one approach that has the potential to improve the quality of health care by allowing practitioners to tailor prevention, diagnostic, and …[more]

Implementing and Evaluating Genomic Screening Programs in Health Care Systems: Proceedings of a Workshop

Implementing and Evaluating Genomic Screening Programs in Health Care Systems: Proceedings of a Workshop

Genomic applications are being integrated into a broad range of clinical and research activities at health care systems across the United States. This trend can be attributed to a variety of factors, including the declining cost of genome sequencing and the potential for improving health outcomes and cutting the costs of care. The goals of …[more]

Human Genome Editing: Science, Ethics, and Governance

Human Genome Editing: Science, Ethics, and Governance

Genome editing is a powerful new tool for making precise alterations to an organism’s genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve …[more]

International Summit on Human Gene Editing: A Global Discussion

International Summit on Human Gene Editing: A Global Discussion

New biochemical tools have made it possible to change the DNA sequences of living organisms with unprecedented ease and precision. These new tools have generated great excitement in the scientific and medical communities because of their potential to advance biological understanding, alter the genomes of microbes, plants, and animals, and treat …[more]

The Science and Applications of Microbial Genomics: Workshop Summary

The Science and Applications of Microbial Genomics: Workshop Summary

Over the past several decades, new scientific tools and approaches for detecting microbial species have dramatically enhanced our appreciation of the diversity and abundance of the microbiota and its dynamic interactions with the environments within which these microorganisms reside. The first bacterial genome was sequenced in 1995 and took …[more]

Perspectives on Higher Education for the New Academic Year

21st century careers require highly skilled workers with strong technical knowledge as well as the ability to solve problems, think creatively, work collaboratively and function as lifelong learners. Recent National Academies studies dive into some of today’s most urgent higher education issues. We asked the Study Directors of each of the publications featured below to highlight actionable recommendations for universities and other stakeholders.

 

“The number of bachelor’s degrees awarded nationally in computer and information science and support services has surged in recent years, increasing by 74 percent between 2009 and 2015, compared to a 16 percent increase in bachelor’s degrees overall. At the same time, interest in computer science courses among majors and non-majors alike has also grown, reflecting the increasing importance of CS skills across disciplines and occupational fields, and in daily life. This report explores the drivers of and potential strategies for responding to this increased demand, noting that there is no one-size-fits-all solution. Academic institutions should respond with urgency to the current demand while planning for the future role of CS institution-wide, taking deliberate actions to support diversity in their programs.” — Emily Grumbling, Study Officer

Assessing and Responding to the Growth of Computer Science Undergraduate Enrollments

The field of computer science (CS) is currently experiencing a surge in undergraduate degree production and course enrollments, which is straining program resources at many institutions and causing concern among faculty and administrators about how best to respond to the rapidly growing demand. …

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“The U.S. system of graduate education for science, technology, engineering, and mathematics (STEM) has long served as an international gold standard by preparing researchers to advance the frontiers of discovery. Given major global challenges such as the rapid innovations in the conduct of research, the role of STEM in the workforce and the economy, and the increasingly diverse backgrounds of students seeking advances degrees, how prepared is the system of graduate education to respond to these changes? The report Graduate STEM Education for the 21st Century calls for cultural change in academic research, which requires adjusting the incentive systems driven in large part by federal and state funding agencies. The incentives often lack alignment with the ideal, student-centric vision of graduate education called for by the committee, which includes support for diverse, equitable, and inclusive learning environments; a system that provides training for mentors and advisors; time and resources for broad career exploration; and increased mental health services. The committee addressed these critical issues, as well as drawing attention to the need for increased data collection in and research on graduate STEM education programs, and provided a series of recommendations to ensure that all stakeholders in the system understand their role in driving change.” — Layne Scherer, Study Officer

Graduate STEM Education for the 21st Century

The U.S. system of graduate education in science, technology, engineering, and mathematics (STEM) has served the nation and its science and engineering enterprise extremely well. Over the course of their education, graduate students become involved in advancing the frontiers of discovery, as …

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“The ‘Branches from the Same Tree’ study explored the impact on students of educational approaches that integrate the humanities and arts with science, engineering, and medicine in higher education. The title of the study is based on a quote from Albert Einstein in which he describes the unity of human knowledge, stating ‘all religions, arts, and sciences are branches from the same tree.’ The study committee found that integrative educational approaches are associated with positive student learning outcomes, including increased critical thinking abilities, higher-order thinking and deeper learning, content mastery, problem solving, teamwork and communication skills, improved visuospatial reasoning, and general engagement and enjoyment of learning. The committee found an incredible groundswell of enthusiasm for integrative educational approaches and catalogued over 200 interdisciplinary, transdisciplinary, and multidisciplinary programs and courses at a diverse array of colleges and universities.” — Ashley Bear, Study Officer

The Integration of the Humanities and Arts with Sciences, Engineering, and Medicine in Higher Education: Branches from the Same Tree

In the United States, broad study in an array of different disciplines —arts, humanities, science, mathematics, engineering— as well as an in-depth study within a special area of interest, have been defining characteristics of a higher education. But over time, in-depth study in a major …

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“There is a growing concern that the biomedical research enterprise, for all of its many strengths, is beset by several core challenges that undercut its vitality, promise, and productivity and that could diminish its critical role in the nation’s health and innovation in the biomedical industry. This is not a new problem – in fact, reports addressing vulnerabilities in the biomedical research workforce have been issued over the last two decades. The committee for the Next Generation Researchers Initiative investigated conclusions from these earlier reports and identified several impediments to progress over the years. A key impediment has been an absence of shared responsibility for the biomedical research system. Many stakeholders in the system tend to hold the federal government responsible for this system, placing blame for failures at the feet of NIH, the principal funder of biomedical research. Doing so, however, obscures the important role that other organizations, particularly universities, must play in developing and implementing solutions. The committee therefore offered several recommendations specifically for universities, as well as a mechanism for shared oversight of the system.” — Lida Beninson, Study Officer

The Next Generation of Biomedical and Behavioral Sciences Researchers: Breaking Through

Since the end of the Second World War, the United States has developed the world’s preeminent system for biomedical research, one that has given rise to revolutionary medical advances as well as a dynamic and innovative business sector generating high-quality jobs and powering economic output …

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“More than 50% of female faculty and staff in higher education and between 20-50% of female students have experienced sexual harassment. Even when the sexual harassment consists of sexist insults or crude behavior, without any unwanted sexual attention or sexual coercion, it can undermine women’s professional and educational attainment and mental and physical health. To stop the pattern of harassing behavior from impacting the next generation of women, a change to the culture and climate in colleges and universities is needed. This report reviews the research on sexual harassment in academia and details how system-wide changes in higher education can be implemented to prevent and address sexual harassment in education and research settings.” — Frazier Benya, Study Officer

Sexual Harassment of Women: Climate, Culture, and Consequences in Academic Sciences, Engineering, and Medicine

Over the last few decades, research, activity, and funding has been devoted to improving the recruitment, retention, and advancement of women in the fields of science, engineering, and medicine. In recent years the diversity of those participating in these fields, particularly the participation …

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Envisioning the Potential of IT to Enhance Health Care, Learning, and Crisis Communication

The National Research Council and the Institute of Medicine have produced a number of reports that address issues of the integration of information technology (IT) into health care, education, and emergency management products. These books explore the potential of IT to support delivery of high-quality health care, impact science education through games and simulations, and alert the public in emergency situations. All are free to download.

Health IT and Patient Safety

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Health IT and Patient Safety: Building Safer Systems for Better Care211 pages | Paperback | Price: $43.20IOM’s 1999 landmark study To Err is Human estimated that between 44,000 and 98,000 lives are lost every year due to medical errors. This call to action has led to a number of efforts to reduce errors and provide safe and effective health care…. [more]

Learning Science Through Computer Games and Simulations

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Learning Science Through Computer Games and Simulations174 pages | Paperback | Price: $35.10At a time when scientific and technological competence is vital to the nation’s future, the weak performance of U.S. students in science reflects the uneven quality of current science education.  Although young children come to school with innate… [more]

Public Response to Alerts and Warnings on Mobile Devices

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Public Response to Alerts and Warnings on Mobile Devices: Summary of a Workshop on Current Knowledge and Research Gaps102 pages | Paperback | Price: $18.90This book presents a summary of the Workshop on Public Response to Alerts and Warnings on Mobile Devices: Current Knowledge and Research Gaps, held April 13 and 14, 2010, in Washington, D.C., under the auspices of the National Research Council’s Committee on… [more]

Digital Infrastructure for the Learning Health System

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Digital Infrastructure for the Learning Health System: The Foundation for Continuous Improvement in Health and Health Care: Workshop Series Summary320 pages | Paperback | Price: $60.97Like many other industries, health care is increasingly turning to digital information and the use of electronic resources. The Institute of Medicine’s Roundtable on Value & Science-Driven Health Care hosted three workshops to explore current efforts and… [more]

Toward Precision Medicine

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Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease142 pages | Paperback | Price: $41.40Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine[more]

Communicating Science and Engineering Data in the Information Age

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Communicating Science and Engineering Data in the Information Age122 pages | Paperback | Price: $34.20The National Center for Science and Engineering Statistics (NCSES) of the National Science Foundation (NSF) communicates its science and engineering (S&E) information to data users in a very fluid environment that is undergoing modernization at a pace at… [more]

Wireless Technology Prospects and Policy Options

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Wireless Technology Prospects and Policy Options112 pages | Paperback | Price: $24.07The use of radio-frequency communication–commonly referred to as wireless communication–is becoming more pervasive as well as more economically and socially important. Technological progress over many decades has enabled the deployment of several successive… [more]

Computational Technology for Effective Health Care

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Computational Technology for Effective Health Care: Immediate Steps and Strategic Directions120 pages | Paperback | Price: $31.50Despite a strong commitment to delivering quality health care, persistent problems involving medical errors and ineffective treatment continue to plague the industry. Many of these problems are the consequence of poor information and technology (IT)… [more]