Tag Archives: vaccines

2021 in Review: Our Reports on Prevention and Response to the Impacts of COVID-19

As of December, more than 800,000 Americans have now died from the COVID-19 virus. Since the beginning of the pandemic in 2020, the U.S. has recorded nearly 50 million cases. In the past year, we have continued to produce reports that guide researchers, policy makers, public health professionals, clinicians, and others who struggle to save lives and support people dealing with the impacts of COVID-19, as well those who build on the lessons learned from this pandemic to prepare for future health crises. As always, these reports are free to read online or download.

Public Health Lessons for Non-Vaccine Influenza Interventions: Looking Past COVID-19

Public Health Lessons for Non-Vaccine Influenza Interventions: Looking Past COVID-19

The COVID-19 pandemic has challenged the world’s preparedness for a respiratory virus event. While the world has been combating COVID-19, seasonal and pandemic influenza remain imminent global health threats. Non-vaccine public health control measures can combat emerging and ongoing influenza …[more]

Globally Resilient Supply Chains for Seasonal and Pandemic Influenza Vaccines

Globally Resilient Supply Chains for Seasonal and Pandemic Influenza Vaccines

Influenza viruses, both seasonal and pandemic, have the potential to disrupt the health and well-being of populations around the world. The global response to the COVID-19 pandemic and prior public health emergencies of international concern illustrate the importance of global preparedness and …[more]

Vaccine Research and Development to Advance Pandemic and Seasonal Influenza Preparedness and Response: Lessons from COVID-19

Vaccine Research and Development to Advance Pandemic and Seasonal Influenza Preparedness and Response: Lessons from COVID-19

The global response to COVID-19 has demonstrated the importance of vigilance and preparedness for infectious diseases, particularly influenza. There is a need for more effective influenza vaccines and modern manufacturing technologies that are adaptable and scalable to meet demand during a …[more]

Countering the Pandemic Threat Through Global Coordination on Vaccines: The Influenza Imperative

Countering the Pandemic Threat Through Global Coordination on Vaccines: The Influenza Imperative

The COVID-19 pandemic has laid bare the fragility of the global system of preparedness and response to pandemics and the fragmentation of our research and development ecosystem. The pandemic has provided a disruptive moment to advance new norms and frameworks for influenza. It also has …[more]

Short-Term Strategies for Addressing the Impacts of the COVID-19 Pandemic on Women's Workforce Participation

Short-Term Strategies for Addressing the Impacts of the COVID-19 Pandemic on Women’s Workforce Participation

The COVID-19 pandemic and the associated recession have significantly affected women’s workforce participation. These impacts have varied from job loss to additional caregiving responsibilities. Black and Hispanic women have been particularly affected, bringing into sharp relief historical …[more]

School-Based Strategies for Addressing the Mental Health and Well-Being of Youth in the Wake of COVID-19

School-Based Strategies for Addressing the Mental Health and Well-Being of Youth in the Wake of COVID-19

COVID-19, along with heightened racial trauma, has caused unprecedented disruption in the lives of youth aged 10-18, leading them to experience increases in mental health concerns. Addressing these negative impacts requires that education leaders, school districts, state and local decision …[more]

Addressing Disaster Vulnerability among Homeless Populations during COVID-19

Addressing Disaster Vulnerability among Homeless Populations during COVID-19

During the COVID-19 pandemic, disruptions to key services for populations experiencing homelessness may lead to secondary effects in the context of a disaster, including effects on health and safety, which require additional population-specific support. Reducing disaster vulnerability for people …[more]

COVID-19 and the Present and Future of Black Communities: The Role of Black Physicians, Engineers, and Scientists: Proceedings of a Workshop

COVID-19 and the Present and Future of Black Communities: The Role of Black Physicians, Engineers, and Scientists: Proceedings of a Workshop

While the COVID-19 pandemic has had devastating health and economic impacts in the United States, communities of color, especially Black communities, have been disproportionately affected. On June 23, 2020, the Roundtable on Black Men and Black Women in Science, Engineering, and Medicine of the …[more]

Rental Eviction and the COVID-19 Pandemic: Averting a Looming Crisis

Rental Eviction and the COVID-19 Pandemic: Averting a Looming Crisis

As the federal moratorium on rental eviction is set to expire on July 31st, 2021, actionable guidance is urgently needed on how to ensure that renters can stay in their homes and housing aid reaches the communities that need it most. This report from the National Academies of Sciences, …[more]

Mental Health and Substance Use Disorders in the Era of COVID-19: The Impact of the Pandemic on Communities of Color: Proceedings of a Workshop—in Brief

Mental Health and Substance Use Disorders in the Era of COVID-19: The Impact of the Pandemic on Communities of Color: Proceedings of a Workshop—in Brief

The Forum on Mental Health and Substance Use Disorders of the National Academies of Sciences, Engineering, and Medicine hosted a virtual workshop, Mental Health and Substance Use Disorders in the Era of COVID-19: With a Special Focus on the Impact of the Pandemic on Communities of Color, on …[more]

Understanding and Communicating about COVID-19 Vaccine Efficacy, Effectiveness, and Equity

Understanding and Communicating about COVID-19 Vaccine Efficacy, Effectiveness, and Equity

Effective communication is needed to ensure shared understanding of how well COVID-19 vaccines work and whether they are being equitably distributed. Without clear, consistent, readily accessible communications, people may lose faith in the vaccines and in those providing them. State, tribal, …[more]

Innovations in Pharmaceutical Manufacturing on the Horizon: Technical Challenges, Regulatory Issues, and Recommendations

Innovations in Pharmaceutical Manufacturing on the Horizon: Technical Challenges, Regulatory Issues, and Recommendations

In 2002, the U.S. Food and Drug Administration (FDA) launched the Pharmaceutical Quality for the 21st Century Initiative to encourage adoption of innovative technologies that would lead to an agile, flexible pharmaceutical manufacturing sector. The goal was to encourage a transition to …[more]

The Impact of COVID-19 on the Careers of Women in Academic Sciences, Engineering, and Medicine

The Impact of COVID-19 on the Careers of Women in Academic Sciences, Engineering, and Medicine

The spring of 2020 marked a change in how almost everyone conducted their personal and professional lives, both within science, technology, engineering, mathematics, and medicine (STEMM) and beyond. The COVID-19 pandemic disrupted global scientific conferences and individual laboratories and …[more]

COVID-19 Addendum to Critical Issues in Transportation

COVID-19 Addendum to Critical Issues in Transportation

The year 2020’s raging coronavirus pandemic and reckoning with long-standing racial injustice led to widespread disruption and suffering, social unrest, and renewed calls for an accounting of our fragmented public health system and troubled history of racial inequity.

The crises of 2020 …[more]

Meeting Regional STEMM Workforce Needs in the Wake of COVID-19: Proceedings of a Virtual Workshop Series

Meeting Regional STEMM Workforce Needs in the Wake of COVID-19: Proceedings of a Virtual Workshop Series

The COVID-19 pandemic is transforming the global economy and significantly shifting workforce demand, requiring quick, adaptive responses. The pandemic has revealed the vulnerabilities of many organizations and regional economies, and it has accelerated trends that could lead to significant …[more]

Rapid Response by Laboratory Animal Research Institutions During the COVID-19 Pandemic: Lessons Learned: Proceedings of a Workshop–in Brief

Rapid Response by Laboratory Animal Research Institutions During the COVID-19 Pandemic: Lessons Learned: Proceedings of a Workshop–in Brief

The National Academies of Sciences, Engineering, and Medicine convened a workshop to explore lessons learned at animal research institutions in response to SARS-CoV-2, the cause of the COVID-19 pandemic. Expert scientists conducting COVID-19 research, as well as institutional leadership …[more]

Learning from Rapid Response, Innovation, and Adaptation to the COVID-19 Crisis: Proceedings of a Workshop–in Brief

Learning from Rapid Response, Innovation, and Adaptation to the COVID-19 Crisis: Proceedings of a Workshop–in Brief

The world continues to grapple with the profound and unprecedented impacts of the COVID-19 pandemic, which by January 2021 had infected more than 90 million people worldwide and taken over 1.9 million lives. The crisis quickly mobilized action by universities, industry, and federal, state, and …[more]

Emergency Evacuation and Sheltering During the COVID-19 Pandemic

Emergency Evacuation and Sheltering During the COVID-19 Pandemic

Fundamental shifts in preparedness planning are needed to ensure health, safety, and smooth operations during emergencies in the context of the COVID-19 pandemic. To prepare for emergency events requiring evacuation, it is necessary to revise shelter planning and mass care operations, shelter …[more]

Critical Findings on COVID-19: Select Publications from the National Academies of Sciences, Engineering, and Medicine

Critical Findings on COVID-19: Select Publications from the National Academies of Sciences, Engineering, and Medicine

For more than 150 years, the National Academies of Sciences, Engineering, and Medicine have issued reports detailing leading research on public health and infectious disease. In response to the global outbreak of COVID-19 in 2020, the National Academies has continued this work by issuing …[more]

Exploring Vaccination Safety

As vaccine research and development continues to grow, so does the debate regarding vaccination safety and best practices. Our reports review the clinical and biological evidence regarding immunization safety.

The Childhood Immunization Schedule and Safety: Stakeholder Concerns, Scientific Evidence, and Future Studies

Vaccines are among the most safe and effective public health interventions to prevent serious disease and death. Because of the success of vaccines, most Americans today have no firsthand experience with such devastating illnesses as polio or …

[more]

Adverse Effects of Vaccines: Evidence and Causality

In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed …

[more]

Building a National Capability to Monitor and Assess Medical Countermeasure Use During a Public Health Emergency: Going Beyond the Last Mile: Proceedings of a Workshop

During public health emergencies (PHEs) involving chemical, biological, radiological, or nuclear threats or emerging infectious diseases, medical countermeasures (MCMs) (e.g., drugs, vaccines, devices) may need to be dispensed or administered to …

[more]

Integrating Clinical Research into Epidemic Response: The Ebola Experience

The 2014–2015 Ebola epidemic in western Africa was the longest and most deadly Ebola epidemic in history, resulting in 28,616 cases and 11,310 deaths in Guinea, Liberia, and Sierra Leone. The Ebola virus has been known since 1976, when two …

[more]

Eliminating the Public Health Problem of Hepatitis B and C in the United States: Phase One Report

Hepatitis B and C cause most cases of hepatitis in the United States and the world. The two diseases account for about a million deaths a year and 78 percent of world’s hepatocellular carcinoma and more than half of all fatal cirrhosis. In 2013 …

[more]

Priorities for the National Vaccine Plan

Vaccination is a fundamental component of preventive medicine and public health. The use of vaccines to prevent infectious diseases has resulted in dramatic decreases in disease, disability, and death in the United States and around the world. …

[more]

Ranking Vaccines: A Prioritization Framework: Phase I: Demonstration of Concept and a Software Blueprint

As a number of diseases emerge or reemerge thus stimulating new vaccine development opportunities to help prevent those diseases, it can be especially difficult for decision makers to know where to invest their limited resources. Therefore, it is …

[more]

Ranking Vaccines: A Prioritization Software Tool: Phase II: Prototype of a Decision-Support System

SMART Vaccines–Strategic Multi-Attribute Ranking Tool for Vaccines–is a prioritization software tool developed by the Institute of Medicine that utilizes decision science and modeling to help inform choices among candidates for new vaccine …

[more]

Ranking Vaccines: Applications of a Prioritization Software Tool: Phase III: Use Case Studies and Data Framework

SMART Vaccines – Strategic Multi-Attribute Ranking Tool for Vaccines – is a prioritization software tool developed by the Institute of Medicine that utilizes decision science and modeling to help inform choices among candidates for new vaccine …

[more]

The Institute of Medicine on the US Measles Outbreak

10707_lores
Photo credit: KidRisk.org

MMR – measles, mumps, rubella – vaccination is again in the news as an outbreak of measles that began at Disneyland before Christmas has spread to six states. As of last Friday, 70 people have been diagnosed with measles, and hundreds more have been exposed at schools, doctor’s offices, hospitals, shopping malls and other places visited by infected patients. Arizona reported its first case of measles related to Disneyland when a woman in her 50s was diagnosed. The outbreak has spread to Utah, Washington, Colorado, Oregon and across the border to Mexico. The Institute of Medicine has produced a number of reports on the safety and importance of vaccination. We asked Kathleen Stratton, an Institute of Medicine Scholar and Study Director of several notable IOM reports on vaccines, for her thoughts on vaccination and public health.

“Vaccines save lives. That’s a fact. We need vaccines developed against some very serious infectious diseases, like respiratory syncytial virus, and we need everyone to heed advice regarding existing vaccines, like the measles vaccine.”

The reports below and others on the subject of vaccination are free to download from our website.

The Childhood Immunization Schedule and Safety: Stakeholder Concerns, Scientific Evidence, and Future Studies

Vaccines are among the most safe and effective public health interventions to prevent serious disease and death. Because of the success of vaccines, most Americans today have no firsthand experience with such devastating illnesses as polio or …

[more]

Infectious Disease Movement in a Borderless World: Workshop Summary

Modern transportation allows people, animals, and plants–and the pathogens they carry–to travel more easily than ever before. The ease and speed of travel, tourism, and international trade connect once-remote areas with one another, eliminating …

[more]

What You Need to Know About Infectious Disease

About a quarter of deaths worldwide–many of them children–are caused by infectious organisms. The World Health Organization reports that new infectious diseases are continuing to emerge and familiar ones are appearing in new locations around …

[more]

Adverse Effects of Vaccines: Evidence and Causality

In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed …

[more]

Immunization Safety Review: Vaccines and Autism

This eighth and final report of the Immunization Safety Review Committee examines the hypothesis that vaccines, specifically the measles-mumps-rubella (MMR) vaccine and thimerosal-containing vaccines, are causally associated with autism. The …

[more]

Science Debate 2012: Vaccination and Public Health

The leading U.S. science and engineering organizations developed a list of 14 science policy questions facing the U.S. in 2012. You can read these questions–and the Presidential candidates’ answers–at ScienceDebate.org.

For each of the Science Debate 2012 questions, we’re going to provide you a selection of the authoritative and unbiased resources of the National Academies to help inform your response to the candidates’ answers. Today, we’re looking at this ScienceDebate question on Vaccinations and Public Health:

Vaccination campaigns against preventable diseases such as measles, polio and whooping cough depend on widespread participation to be effective, but in some communities vaccination rates have fallen off sharply. What actions would you support to enforce vaccinations in the interest of public health, and in what circumstances should exemptions be allowed?

How would you respond? Download these reports for free at NAP.edu or purchase a print copy to read.

 

Adverse Effects of Vaccines

Download Free PDF

Adverse Effects of Vaccines: Evidence and Causality892 pages | Hardcover | Price: $71.95In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was… [more]
Immunization Safety Review

Download Free PDF

Immunization Safety Review: Measles-Mumps-Rubella Vaccine and Autism102 pages | Paperback | Price: $25.20Immunization is widely regarded as one of the most effective and beneficial tools for protecting the public’s health. In the United States, immunization programs have resulted in the eradication of smallpox, the elimination of polio, and the control and near… [more]
Priorities for the National Vaccine Plan

Download Free PDF

Priorities for the National Vaccine Plan368 pages | Paperback | Price: $51.30Vaccination is a fundamental component of preventive medicine and public health. The use of vaccines to prevent infectious diseases has resulted in dramatic decreases in disease, disability, and death in the United States and around the world. The current… [more]
Ranking Vaccines

Download Free PDF

Ranking Vaccines: A Prioritization Framework: Phase I: Demonstration of Concept and a Software Blueprint170 pages | Paperback | Price: $54.00As a number of diseases emerge or reemerge thus stimulating new vaccine development opportunities to help prevent those diseases, it can be especially difficult for decision makers to know where to invest their limited resources. Therefore, it is increasingly… [more]
For the Public's Health

Download Free PDF

For the Public’s Health: Revitalizing Law and Policy to Meet New Challenges140 pages | Paperback | Price: $35.10The Robert Wood Johnson Foundation asked the Institute of Medicine (IOM) to examine three topics in relation to public health: measurement, the law, and funding. IOM prepared a three book series-one book on each topic-that contain actionable recommendations… [more]

Ten New Science Books: Lab Animals, Vaccines, Cancer Care, and more…

We’ve been a little quiet lately here at Notes From NAP, due largely to some technical tinkering we’ve needed to do as the summer quietly moves in, so our apologies. We’re back with a bang, though: Guide for the Care and Use of Laboratory Animals was released last week, and is our featured publication of the week. See more publications in the topic of Lab Animal Research.

Featured Publication

Guide for the Care and Use of Laboratory Animals (prepublication)

A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use:

Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals.

Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee.

Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more.

Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia.

Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs.

The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

All New Publications This Week

Considerations for Ensuring Safety and Efficacy of Vaccines and Therapeutic Proteins Manufactured by Using Platform Approaches: Summary of a Workshop (forthcoming)

A Foundation for Evidence-Drive Practice: A Rapid Learning System for Cancer Care: Workshop Summary (prepublication)

Assessment of Technologies for Improving Light Duty Vehicle Fuel Economy (prepublication)

A Summary of the December 2009 Forum on the Future of Nursing: Care in the Community (final)

Residential Energy Consumption Letter Report (final)

Hidden Costs of Energy: Unpriced Consequences of Energy Production and Use (final)

Achieving Effective Acquisition of Information Technology in the Department of Defense (final)

The Public Health Emergency Medical Countermeasures Enterprise: Innovative Strategies to Enhance Products from Discovery Through Approval: Workshop Summary (final)

Regionalizing Emergency Care: Workshop Summary (final)