Tag Archives: human genome

Explore the Possibilities and Challenges of Biotechnology

Fundamental, emerging, and applied life science and biotechnology research are critical to the bioeconomy, science, health, agriculture, energy, the environment, and national security and defense. The biotechnology economy is growing rapidly, with the scale, scope, and complexity of products increasing. Our titles address critical, emerging policy and technical issues associated with the life sciences and biotechnology research and their applications.

Physics of Life

Physics of Life

Biological physics, or the physics of living systems, has emerged fully as a field of physics, alongside more traditional fields of astrophysics and cosmology, atomic, molecular and optical physics, condensed matter physics, nuclear physics, particle physics, and plasma physics. This new field brings the physicist’s style of inquiry to bear on …[more]

Heritable Human Genome Editing

Heritable Human Genome Editing

Heritable human genome editing – making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy – raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have …[more]

Safeguarding the Bioeconomy

Safeguarding the Bioeconomy

Research and innovation in the life sciences is driving rapid growth in agriculture, biomedical science, information science and computing, energy, and other sectors of the U.S. economy. This economic activity, conceptually referred to as the bioeconomy, presents many opportunities to create jobs, improve the quality of life, and continue to …[more]

Forest Health and Biotechnology: Possibilities and Considerations

Forest Health and Biotechnology: Possibilities and Considerations

The American chestnut, whitebark pine, and several species of ash in the eastern United States are just a few of the North American tree species that have been functionally lost or are in jeopardy of being lost due to outbreaks of pathogens and insect pests. New pressures in this century are putting even more trees at risk. Expanded human …[more]

Biodefense in the Age of Synthetic Biology

Biodefense in the Age of Synthetic Biology

Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly …[more]

Human Genome Editing: Science, Ethics, and Governance

Human Genome Editing: Science, Ethics, and Governance

Genome editing is a powerful new tool for making precise alterations to an organism’s genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve …[more]

Preparing for Future Products of Biotechnology

Preparing for Future Products of Biotechnology

Between 1973 and 2016, the ways to manipulate DNA to endow new characteristics in an organism (that is, biotechnology) have advanced, enabling the development of products that were not previously possible. What will the likely future products of biotechnology be over the next 5–10 years? What scientific capabilities, tools, and/or expertise …[more]

Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values

Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values

Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to …[more]

Genetically Engineered Crops: Experiences and Prospects

Genetically Engineered Crops: Experiences and Prospects

Genetically engineered (GE) crops were first introduced commercially in the 1990s. After two decades of production, some groups and individuals remain critical of the technology based on their concerns about possible adverse effects on human health, the environment, and ethical considerations. At the same time, others are concerned that the …[more]

New Frontiers of Biomedical Science: Possibilities and Issues

Credit: American Cancer Institute

As scientific advances have made genome editing and other biomedical technologies more efficient, precise, and flexible than ever before, scientists, patients, and others have been exploring possible ways in which this cutting-edge science can improve human health. Our titles consider both the potential benefits and the scientific, ethical, legal, social, and governance issues associated with the use of gene-editing tools and other new technologies. As always, all are free to read online or download.

The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance

The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance

Each year, tens of millions of individuals in the U.S. suffer from neurological and psychiatric disorders including neurodegenerative diseases such as Alzheimer’s Disease and Parkinson’s Disease, and psychiatric disorders such as autism spectrum disorder, depression and schizophrenia. Treatments for these diseases are often completely …[more]

Next Steps for Functional Genomics: Proceedings of a Workshop

Next Steps for Functional Genomics: Proceedings of a Workshop

One of the holy grails in biology is the ability to predict functional characteristics from an organism’s genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism’s phenotype, its physical …[more]

Heritable Human Genome Editing

Heritable Human Genome Editing

Heritable human genome editing – making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy – raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have …[more]

Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting: Proceedings of a Workshop

Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting: Proceedings of a Workshop

Sharing knowledge is what drives scientific progress – each new advance or innovation in biomedical research builds on previous observations. However, for experimental findings to be broadly accepted as credible by the scientific community, they must be verified by other researchers. An essential step is for researchers to report their findings …[more]

Safeguarding the Bioeconomy

Safeguarding the Bioeconomy

Research and innovation in the life sciences is driving rapid growth in agriculture, biomedical science, information science and computing, energy, and other sectors of the U.S. economy. This economic activity, conceptually referred to as the bioeconomy, presents many opportunities to create jobs, improve the quality of life, and continue to …[more]

Framework for Addressing Ethical Dimensions of Emerging and Innovative Biomedical Technologies: A Synthesis of Relevant National Academies Reports

Framework for Addressing Ethical Dimensions of Emerging and Innovative Biomedical Technologies: A Synthesis of Relevant National Academies Reports

Over the past 15 years, the National Academies of Sciences, Engineering, and Medicine (the National Academies) have convened multiple committees of leading experts to address ethical challenges related to innovative and emerging biomedical technologies. After reviewing prior National Academies’ reports, individual ethics principles and …[more]

Second International Summit on Human Genome Editing: Continuing the Global Discussion: Proceedings of a Workshop–in Brief

Second International Summit on Human Genome Editing: Continuing the Global Discussion: Proceedings of a Workshop–in Brief

On November 27-29, 2018, the U.S. National Academy of Sciences and U.S. National Academy of Medicine, the Royal Society of the United Kingdom, and the Academy of Sciences of Hong Kong convened the Second International Summit on Human Genome Editing at the University of Hong Kong. The summit brought together more than 500 researchers, ethicists, …[more]

Understanding Disparities in Access to Genomic Medicine: Proceedings of a Workshop

Understanding Disparities in Access to Genomic Medicine: Proceedings of a Workshop

Genomic medicine is defined as the routine use of genomic information about an individual as part of his or her clinical care as well as the health outcomes and policy implications of that clinical use. It is one approach that has the potential to improve the quality of health care by allowing practitioners to tailor prevention, diagnostic, and …[more]

Implementing and Evaluating Genomic Screening Programs in Health Care Systems: Proceedings of a Workshop

Implementing and Evaluating Genomic Screening Programs in Health Care Systems: Proceedings of a Workshop

Genomic applications are being integrated into a broad range of clinical and research activities at health care systems across the United States. This trend can be attributed to a variety of factors, including the declining cost of genome sequencing and the potential for improving health outcomes and cutting the costs of care. The goals of …[more]

Human Genome Editing: Science, Ethics, and Governance

Human Genome Editing: Science, Ethics, and Governance

Genome editing is a powerful new tool for making precise alterations to an organism’s genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve …[more]

International Summit on Human Gene Editing: A Global Discussion

International Summit on Human Gene Editing: A Global Discussion

New biochemical tools have made it possible to change the DNA sequences of living organisms with unprecedented ease and precision. These new tools have generated great excitement in the scientific and medical communities because of their potential to advance biological understanding, alter the genomes of microbes, plants, and animals, and treat …[more]

The Science and Applications of Microbial Genomics: Workshop Summary

The Science and Applications of Microbial Genomics: Workshop Summary

Over the past several decades, new scientific tools and approaches for detecting microbial species have dramatically enhanced our appreciation of the diversity and abundance of the microbiota and its dynamic interactions with the environments within which these microorganisms reside. The first bacterial genome was sequenced in 1995 and took …[more]

Sequencing the Human Genome – Applications, Ethics, and Implications

In honor of National DNA Day, explore new technologies and treatments that have resulted from the sequencing of the human genome and their ethical, medical, and societal implications. As always, our publications are free to read online or download.

Human Genome Editing: Science, Ethics, and Governance

Genome editing is a powerful new tool for making precise alterations to an organism’s genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an …

[more]

Second International Summit on Human Genome Editing: Continuing the Global Discussion: Proceedings of a Workshop–in Brief

On November 27-29, 2018, the U.S. National Academy of Sciences and U.S. National Academy of Medicine, the Royal Society of the United Kingdom, and the Academy of Sciences of Hong Kong convened the Second International Summit on Human Genome …

[more]

International Summit on Human Gene Editing: A Global Discussion

New biochemical tools have made it possible to change the DNA sequences of living organisms with unprecedented ease and precision. These new tools have generated great excitement in the scientific and medical communities because of their …

[more]

The Promise of Genome Editing Tools to Advance Environmental Health Research: Proceedings of a Workshop—in Brief

Advances in genome editing – the process for making precise additions, deletions, and alterations of DNA and RNA – have opened the door for studying biological mechanisms of health and disease. On January 10-11, 2018, the National Academies of …

[more]

Biodefense in the Age of Synthetic Biology

Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and …

[more]

Mitochondrial Replacement Techniques: Ethical, Social, and Policy Considerations

Mitochondrial replacement techniques (MRTs) are designed to prevent the transmission of mitochondrial DNA (mtDNA) diseases from mother to child. While MRTs, if effective, could satisfy a desire of women seeking to have a genetically related child …

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The Economics of Genomic Medicine: Workshop Summary

The sequencing of the human genome and the identification of links between specific genetic variants and diseases have led to tremendous excitement over the potential of genomics to direct patient treatment toward more effective or less harmful …

[more]

Genome-Based Diagnostics: Demonstrating Clinical Utility in Oncology: Workshop Summary

Genome-Based Diagnostics: Demonstrating Clinical Utility in Oncology is the summary of a workshop convened in May 2012 by the Roundtable on Translating Genomic-Based Research for Health and the Center for Medical Technology Policy of the …

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Genome-Based Therapeutics: Targeted Drug Discovery and Development: Workshop Summary

The number of new drug approvals has remained reasonably steady for the past 50 years at around 20 to 30 per year, while at the same time the total spending on health-related research and development has tripled since 1990. There are many …

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Genome-Based Diagnostics: Clarifying Pathways to Clinical Use: Workshop Summary

The sequencing of the human genome and the identification of associations between specific genetic variants and diseases have led to an explosion of genomic-based diagnostic tests. These tests have the potential to direct therapeutic …

[more]

Integrating Large-Scale Genomic Information into Clinical Practice: Workshop Summary

The initial sequencing of the human genome, carried out by an international group of experts, took 13 years and $2.7 billion to complete. In the decade since that achievement, sequencing technology has evolved at such a rapid pace that today a …

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Direct-to-Consumer Genetic Testing: Summary of a Workshop

Today, scores of companies, primarily in the United States and Europe, are offering whole genome scanning services directly to the public. The proliferation of these companies and the services they offer demonstrate a public appetite for this …

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Evolution of Translational Omics: Lessons Learned and the Path Forward

Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using …

[more]

Mapping and Sequencing the Human Genome

There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will …

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