Tag Archives: massive data

Sharing Clinical Trial Data to Advance Scientific Discovery and Improve Care

Clinical trials generate vast amounts of data, yet a large portion of this information is never published or made available to other researchers. Data sharing could advance scientific discovery and improve clinical care, but it involves potential risks and costs for key stakeholders, including clinical trialists, sponsors, researchers, and patients. Our publications discuss the challenges and opportunities for stakeholders to better harmonize incentives, policy, data standards, and governance to encourage the sharing and reuse of clinical trial data sharing.

Sharing Clinical Trial Data: Maximizing Benefits, Minimizing Risk

Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and …

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The Prevention and Treatment of Missing Data in Clinical Trials

Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors …

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Sharing Clinical Research Data: Workshop Summary

Pharmaceutical companies, academic researchers, and government agencies such as the Food and Drug Administration and the National Institutes of Health all possess large quantities of clinical research data. If these data were shared more widely …

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Biomarker Tests for Molecularly Targeted Therapies: Key to Unlocking Precision Medicine

Every patient is unique, and the evolving field of precision medicine aims to ensure the delivery of the right treatment to the right patient at the right time. In an era of rapid advances in biomedicine and enhanced understanding of the genetic …

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Discussion Framework for Clinical Trial Data Sharing: Guiding Principles, Elements, and Activities

Sharing data generated through the conduct of clinical trials offers the promise of placing evidence about the safety and efficacy of therapies and clinical interventions on a firmer basis and enhancing the benefits of clinical trials. …

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A National Cancer Clinical Trials System for the 21st Century: Reinvigorating the NCI Cooperative Group Program

The National Cancer Institute’s (NCI) Clinical Trials Cooperative Group Program has played a key role in developing new and improved cancer therapies. However, the program is falling short of its potential, and the IOM recommends changes that aim …

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Ovarian Cancers: Evolving Paradigms in Research and Care

In an era of promising advances in cancer research, there are considerable and even alarming gaps in the fundamental knowledge and understanding of ovarian cancer. Researchers now know that ovarian cancer is not a single disease–several distinct …

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The Top 20 Most Popular Titles Of 2013

As we approach the end of the year, we’re taking a quick look back at the best selling books that were released in 2013. In just the top 20 titles of the year, we can see the incredible variety of topics covered in the reports of the National Academies, including education, cancer care, preventing obesity, alternative vehicles and fuels, veterinary medicine, data, solar and space physics, veteran’s health, mathematical sciences, climate change and sports-related concussions.

Our list, ranked from our #1 top seller of 2013, is below. When you’re done looking through the list, take a little time to browse through all of the topics we cover.

1. Next Generation Science Standards: For States, By States

Next Generation Science Standards identifies the science all K-12 students should know. These new standards are based on the National Research Council’s A Framework for K-12 Science Education. The National Research Council, the … [more]

2. Best Care at Lower Cost: The Path to Continuously Learning Health Care in America

America’s health care system has become too complex and costly to continue business as usual. Best Care at Lower Cost explains that inefficiencies, an overwhelming amount of data, and other economic and quality barriers hinder progress … [more]

3. U.S. Health in International Perspective: Shorter Lives, Poorer Health

The United States is among the wealthiest nations in the world, but it is far from the healthiest. Although life expectancy and survival rates in the United States have improved dramatically over the past century, Americans live shorter lives … [more]

4. Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis

In the United States, approximately 14 million people have had cancer and more than 1.6 million new cases are diagnosed each year. However, more than a decade after the Institute of Medicine (IOM) first studied the quality of cancer care, the … [more]

5. Interprofessional Education for Collaboration: Learning How to Improve Health from Interprofessional Models Across the Continuum of Education to Practice: Workshop Summary

Every year, the Global Forum undertakes two workshops whose topics are selected by the more than 55 members of the Forum. It was decided in this first year of the Forum’s existence that the workshops should lay the foundation for future work of … [more]

6. Reforming Juvenile Justice: A Developmental Approach

Adolescence is a distinct, yet transient, period of development between childhood and adulthood characterized by increased experimentation and risk-taking, a tendency to discount long-term consequences, and heightened sensitivity to peers and … [more]

7. Alternatives for Managing the Nation’s Complex Contaminated Groundwater Sites

Across the United States, thousands of hazardous waste sites are contaminated with chemicals that prevent the underlying groundwater from meeting drinking water standards. These include Superfund sites and other facilities that handle and dispose … [more]

8. Evaluating Obesity Prevention Efforts: A Plan for Measuring Progress

Obesity poses one of the greatest public health challenges of the 21st century, creating serious health, economic, and social consequences for individuals and society. Despite acceleration in efforts to characterize, comprehend, and act on this … [more]

9. Variation in Health Care Spending: Target Decision Making, Not Geography

Health care in the United States is more expensive than in other developed countries, costing $2.7 trillion in 2011, or 17.9 percent of the national gross domestic product. Increasing costs strain budgets at all levels of government and threaten … [more]

10. Transitions to Alternative Vehicles and Fuels

For a century, almost all light-duty vehicles (LDVs) have been powered by internal combustion engines operating on petroleum fuels. Energy security concerns about petroleum imports and the effect of greenhouse gas (GHG) emissions on global … [more]

11. Frontiers in Massive Data Analysis

Data mining of massive data sets is transforming the way we think about crisis response, marketing, entertainment, cybersecurity and national intelligence. Collections of documents, images, videos, and networks are being thought of not merely as … [more]

12. Educating the Student Body: Taking Physical Activity and Physical Education to School

Physical inactivity is a key determinant of health across the lifespan. A lack of activity increases the risk of heart disease, colon and breast cancer, diabetes mellitus, hypertension, osteoporosis, anxiety and depression and others diseases. … [more]

13. Solar and Space Physics: A Science for a Technological Society

From the interior of the Sun, to the upper atmosphere and near-space environment of Earth, and outward to a region far beyond Pluto where the Sun’s influence wanes, advances during the past decade in space physics and solar physics–the … [more]

14. Optics and Photonics: Essential Technologies for Our Nation

Optics and photonics technologies are ubiquitous: they are responsible for the displays on smart phones and computing devices, optical fiber that carries the information in the internet, advanced precision manufacturing, enhanced defense … [more]

15. Returning Home from Iraq and Afghanistan: Assessment of Readjustment Needs of Veterans, Service Members, and Their Families

As of December 2012, Operation Enduring Freedom (OEF) in Afghanistan and Operation Iraqi Freedom (OIF) in Iraq have resulted in the deployment of about 2.2 million troops; there have been 2,222 US fatalities in OEF and Operation New Dawn (OND)1 … [more]

16. Workforce Needs in Veterinary Medicine

The U.S. veterinary medical profession contributes to society in diverse ways, from developing drugs and protecting the food supply to treating companion animals and investigating animal diseases in the wild. In a study of the issues related to … [more]

17. The Mathematical Sciences in 2025

The mathematical sciences are part of nearly all aspects of everyday life–the discipline has underpinned such beneficial modern capabilities as Internet search, medical imaging, computer animation, numerical weather predictions, and all types of … [more]

18. Sports-Related Concussions in Youth: Improving the Science, Changing the Culture

In the past decade, few subjects at the intersection of medicine and sports have generated as much public interest as sports-related concussions – especially among youth. Despite growing awareness of sports-related concussions and campaigns to … [more]

19. Abrupt Impacts of Climate Change: Anticipating Surprises

Climate is changing, forced out of the range of the past million years by levels of carbon dioxide and other greenhouse gases not seen in the Earth’s atmosphere for a very, very long time. Lacking action by the world’s nations, it is clear that … [more]

20. Using Science to Improve the BLM Wild Horse and Burro Program: A Way Forward

Using Science to Improve the BLM Wild Horse and Burro Program: A Way Forward reviews the science that underpins the Bureau of Land Management’s oversight of free-ranging horses and burros on federal public lands in the western United … [more]